Personnel de l'université

Gérald REMAUD

Professeur dans l'équipe EBSI au sein de CEISAM UMR CNRS 6230 à l'UFR des Sciences. Responsable de l'équipe EBSI. Responsable du Master 2 A3M, ouvert en alternance par contrat d'apprentissage

Coordonnées

CEISAM, UMR CNRS6230, 2 rue de la Houssinière, BP 92208, Nantes 44322 cedex 3, France

Tél
0251125719 (n° interne : 455719)
Fax
02 51 12 57 12
Mail
Gerald.Remaud@univ-nantes.fr

Discipline(s) enseignée(s)

RMN, Assurance Qualité-Contrôle Qualité, Chimie bio-organique, Wet chemistry

Thèmes de recherche

Chimie analytique, Mesure des effets isotopiques, RMN quantitative, Coordinateur : du projet ANR "ISOTO-POL" N° ANR 2011 CESA 009 01 du projet régional 'stratégie internationale' PLAISIR du projet ANR "FRIIME"

Activités / CV

Quelques publications récentes qui illustrent mes activités de recherche : 

- Unexpected Fractionation in Site-Specific 13C Isotopic Distribution Detected by Quantitative 13C NMR at Natural Abundance

Eliot P. Botosoa, Elsa Caytan, Virginie Silvestre, Richard J. Robins, Serge Akoka, and Gérald S. Remaud

Journal  of American Chemical Society 2008, 130, 414-415

- Quantitative isotopic 13C nuclear magnetic resonance at natural abundance to probe enzyme reaction mechanisms via site-specific isotope fractionation: The case of the chain-shortening reaction for the bioconversion of ferulic acid to vanillin

Eliot P. Botosoa, Christine Blumenstein, Donald A. MacKenzie, Virginie Silvestre, Gérald S. Remaud,Renata A. Kwiecien, Richard J. Robins

Analytical Biochemistry 2009, 393, 182-188


- Evaluation of Ultrafast 2D NMR for Quantitative Analysis

Patrick Giraudeau, Gérald S. Remaud, and Serge Akoka

Analytical Chemistry  2009, 81, 479-484


- Isotopic 13C NMR spectrometry to assess counterfeiting of active pharmaceutical ingredients: Site-specific 13C content of aspirin and paracetamol

Virginie Silvestre, Vanessa Maroga Mboula, Catherine Jouitteau, Serge Akoka, Richard J; Robins, Gérald Remaud

Journal of Pharmaceutical and Biomedical Analysis 2009, 50, 336-341

- Accurate quantitative isotopic 13C NMR spectroscopy for the determination of the intramolecular distribution of 13C in glucose at natural abundance

Alexis Gilbert, Virginie Silvestre, Richard J. Robins, Gérald S. Remaud

Analytical Chemistry 2009, 81, 8978-8985


- Performance evaluation of quantitative adiabatic 13C NMR pulse sequences for site-specific isotopic measurements

Christophe Thibaudeau, Gérald Remaud, Virginie Silvestre Serge Akoka

Analytical Chemistry 2010, 82, 5582-5590

- Improved characterization of the botanical origin of sugar by carbon-13 SNIF-NMR applied to ethanol.

F. Thomas, C. Randet, A. Gilbert, V. Silvestre, E. Jamin, S. Akoka, G. Remaud, N. Segebarth, C. Guillou,

Journal of Agricultural and. Food Chemistry 2010, 58, 11580-11585


- A 13C NMR spectrometric method to determine the intramolecular d13C values in fructose from plant sucrose samples.

A. Gilbert, V. Silvestre, R.J. Robins, G. Tcherkez, G.S. Remaud,

New Phytologist 2011, 191, 579-588


- The intramolecular 13C-distribution in ethanol reveals the influence of the CO2-fixation pathway and environmental conditions on the site-specific 13C variation in glucose.

A. Gilbert, V. Silvestre, N. Segebarth, G. Tcherkez, C. Guillou, R.J. Robins, S.  Akoka, G.S. Remaud,

Plant, Cell and Environment 2011, 34, 1104-1112

- Isotopic finger-printing of active pharmaceutical ingredients by 13C NMR and polarization transfer techniques as a tool to fight against counterfeiting.
Ugo Bussy, Christophe Thibaudeau, Freddy Thomas, Jean-Roger Desmurs, Eric Jamin, Gérald S. Remaud, Virginie Silvestre, Serge Akoka

Talanta 2011, 85, 1909- 1914

- Analytical model for site-specific isotope fractionation in 13C during sorption: Determination by isotopic 13C NMR spectrometry with vanillin as model compound.

Patrick Höhener, Virginie Silvestre, Anaïs Lefrançois, Denis Loquet, Eliot P. Botosoa, Richard J. Robins, Gérald S. Remaud

Chemosphere, 2012, 87, 445-452

- Biochemical and physiological determinants of intramolecular isotope
patterns in sucrose from C3, C4 and CAM plants accessed by isotopic 13C NMR spectrometry: a viewpoint.

A. Gilbert, V. Silvestre, R.J. Robins, G.S. Remaud, G. Tcherkez

Nat. Prod. Rep., 2012, 29, 476-486

- Intramolecular 13C-pattern in hexoses from autotrophic and heterotrophic C3 plant tissues.

 Gilbert, A., Robins, R.J., Remaud, G.S., Tcherkez, G.

Proc. Natl. Acad. Sci. USA, 2012, 109 , 18204-18209. .

- NMR spectrometry isotopic fingerprinting: A tool for the manufacturer for tracking Active Pharmaceutical Ingredients from starting materials to final medicines.

Gérald S. Remaud, Ugo Bussy, Michèle Lees, Freddy Thomas, Jean-Roger Desmurs, Eric Jamin, Virginie Silvestre, Serge Akoka.

European Journal of Pharmaceutical Sciences 48 (2013) 464-473

- Conditions to obtain precise and true measurements of the intramolecular 13C distribution in organic molecules by isotopic 13C nuclear magnetic resonance spectrometry.

K. Bayle, A. Gilbert, M. Julien, K. Yamada, V. Silvestre, R.J. Robins, S. Akoka, N. Yoshida, G.S. Remaud

Analytica Chimica Acta 846 (2014) 1-7.

- Insights into Mechanistic Models for Evaporation of Organic Liquids in the Environment Obtained by Position-Specific Carbon Isotope Analysis.

M. Julien, P. Nun, R.J. Robins, G.S. Remaud, J. Parinet, P. Höhener

Environ. Sci. Technol. 49 12782-12788 (2015).

A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol

K.M. Romeka, P. Nun, G.S. Remaud, V. Silvestre, G. Sotoing Taïwe, F. Lecerf-Schmidt, A. Boumendjeld, M. De Waarde, R.J. Robins

Proc. Natl. Acad. Sci. USA 112 8296-8301 (2015).