Coordonnées
"Stress adaptation and tumor escape in breast cancer" Institut de Recherche Thérapeutique de l’Université de Nantes 8 Quai Moncousu BP 70721 44007 Nantes Cedex 1 France
- Bureau
- IRS-UN Room 421
- Philippe.Juin@univ-nantes.fr
- Site internet
- http://www.crcina.org/recherche/departement-2-onco/equipe-08-stress-adaptation-and-tumor-escape-in-breast-cancer/
Discipline(s) enseignée(s)
Thèmes de recherche
My research team studies mechanisms controlling mitochondrial integrity in cells that compose epithelial tumor ecosystems.
Why? Because these mechanisms, critically regulated by BCL-2 family proteins, influence tumor progression. They convert stress cues associated with pathologic growth and treatments into mitochondrial permeabilization/protection inputs, leading to individual cell death/survival decisions and damage signalling.
With what purpose? To define anti-tumor approaches based on the deleterious exacerbation of this “mitochondrial permeabilization stress” and/or on the exploitation of its extrinsic effects. The applied objective of our fundamental research on the modulation of tumor evolution by mitochondrial integrity control is to optimize the anti-tumor effects of BH3 mimetics targeting BCL-2 homologues.