Personnel de l'université

Philippe JUIN



"Stress adaptation and tumor escape in breast cancer" Institut de Recherche Thérapeutique de l’Université de Nantes 8 Quai Moncousu BP 70721 44007 Nantes Cedex 1 France

IRS-UN Room 421
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Discipline(s) enseignée(s)

Biology and biochemistry of cell death

Thèmes de recherche

My research team studies mechanisms controlling mitochondrial integrity in cells that compose epithelial tumor ecosystems.

Why? Because these mechanisms, critically regulated by BCL-2 family proteins, influence tumor progression. They convert stress cues associated with pathologic growth and treatments into mitochondrial permeabilization/protection inputs, leading to individual cell death/survival decisions and damage signalling.

With what purpose? To define anti-tumor approaches based on the deleterious exacerbation of this “mitochondrial permeabilization stress” and/or on the exploitation of its extrinsic effects. The applied objective of our fundamental research on the modulation of tumor evolution by mitochondrial integrity control is to optimize the anti-tumor effects of BH3 mimetics targeting BCL-2 homologues.

Informations complémentaires

Researcher ID: H-3636-2014