Jean-Nicolas DUMEZ

Nuclear Magnetic Resonance (NMR) spectroscopy provides an unparalleled level of information, at the atomic scale, on systems ranging from molecules in solutions to living organisms. The scope of NMR, however, is limited by it poor sensitivity, as well as the time required to record information-rich multidimensional experiments. We work on the development of fast and sensitive NMR methods for solution-state studies of small molecules. In particular, we exploit and expand the concepts of ultrafast 2D NMR which yields multidimensional spectra in a single scan, as well as hyperpolarisation, which enhances NMR signals by several orders of magnitude. This research is based on fundamental aspects of spin dynamics, with the aim of developing novel approaches to characterise chemical systems and in particular complex mixtures of small molecules. Specific areas of application include metabolomics as well as the monitoring of chemical reactions.

Ongoing grants:

• ANR young researcher grant "SENSOR" 2017 – 2020
• ERC Starting Grant "DINAMIX", 2019 – 2023
• Connect Talent grant of the Region Pays de la Loire 2019 – 2023

2018 – present : CNRS associate scientist at the CEISAM – Université de Nantes
2014 – 2018 : CNRS associate scientist at ICSN – Université Paris-Saclay
2013 – 2014 : Post-doctoral Fellow at the University of Southampton
2011 – 2013 : Post-doctoral Fellow at the Weizmann Institute of Science
2009 – 2011 : Ph.D. student at the CRMN – ENS de Lyon
2004 – 2008 : Elève at the ENS de Lyon

Full publication list http://orcid.org/0000-0002-5394-8001

Selected publications:

• J.-N. Dumez, Spatial encoding and spatial selection methods in high-resolution NMR spectroscopy, Prog. Nucl. Magn. Reson. Spectrosc., 109, 101 (2018). http://dx.doi.org/10.1016/j.pnmrs.2018.08.001
• L. Guduff, D. Kurzbach, C. van Heijenoort, D. Abergel and J.-N. Dumez, Single-scan 13C diffusion-ordered NMR spectroscopy of DNP-hyperpolarised substrates, Chem. Eur. J., 23, 16722 (2017). 
  http://dx.doi.org/10.1002/chem.201703300
• L. Guduff, I. Kuprov, C. van Heijenoort and J.-N. Dumez, Spatially encoded 2D and 3D diffusion- ordered NMR spectroscopy, Chem. Commun., 53, 701 (2017). 
  http://dx.doi.org/10.1039/C6CC09028A
• V. Daniele, F.-X. Legrand, P. Berthault, J.-N. Dumez and G. Huber, Single-Scan Multidimensional NMR Analysis of Mixtures at Sub-Millimolar Concentrations by using SABRE Hyperpolarization, ChemPhysChem, 16, 3413 (2015).
  http://dx.doi.org/10.1002/cphc.201500535
• J.-N. Dumez, J. Milani, B. Vuichoud, A. Bornet, J. Lalande-Martin, I. Tea, M. Yon, M. Maucourt, C. Deborde, A. Moing, L. Frydman, G. Bodenhausen, S. Jannin and P. Giraudeau, Hyperpolarized NMR of plant and cancer cell extracts at natural abundance, Analyst, 140, 5860 (2015). 
  http://dx.doi.org/10.1039/c5an01203a
• J.-N. Dumez, P. Hakansson, S. Mamone, B. Meier, G. Stevanato, J.T. Hill-Cousins, S.S. Roy R.C.D. Brown, G. Pileio and M.H. Levitt, Theory of long-lived nuclear spin states in methyl groups and quantum-rotor-induced polarization, J. Chem. Phys. 142, 044506 (2015). http://dx.doi.org/10.1063/1.4906273