Personnel de l'université
Eloïse GRASSET
Chercheuse, CDDCoordonnées
IRS UN - 8 Quai Moncousu - BP 70721 44007 NANTES cedex 1, France
Thèmes de recherche
Despite significant progress in diagnostic and treatment modalities, breast cancer metastases persist as a prominent public health concern. Addressing the challenge of metastasis formation and development requires a deeper comprehension of how cancer cells colonize and adapt to distant sites.
Our research group is committed to unraveling the intricate cellular and molecular mechanisms underlying the formation of breast cancer metastases, with the ultimate goal of pioneering novel therapies to combat metastatic disease. Employing a comprehensive approach, we integrate state-of-the-art techniques such as primary organoid culture, single-cell RNA sequencing, and advanced imaging methods. Through these methodologies, we aim to contribute meaningful insights to the field and advance the development of effective interventions against breast cancer metastasis.
Vidéo réalisée par la FRM sur un de nos projets de recherche
Activités / CV
Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells. Eloise M. Grasset, Atul Desphande, Jae W. Lee, Yeonju Cho, Sarah M. Shin, Erin M. Coyne, Alexei Hernandez, Xuan Yuan, Zhehao Zhang, Ashley Cimino-Matthews, Andrew J. Ewald, Won Jin Ho. BioRxiv. https://doi.org/10.1101/2024.03.15.585195
Stress in the metastatic journey: role of cell communication and clustering in breast cancer progression and treatment resistance. Grasset EM*, Barillé-Nion S, Juin PP. Disease Models and Mechanisms (2024) 17 (3): dmm050542. https://doi.org/10.1242/dmm.050542Triple negative breast tumors contain heterogeneous cancer cells expressing distinct KRAS-dependent collective and disseminative invasion programs. Henriet E, Knutsdottir H, Grasset EM, Dunworth M, Haynes M, Bader JS, Ewald AJ. Oncogene 42, 737–747 (2023).
Triple negative breast cancer metastasis involves complex EMT dynamics and requires vimentin. Grasset EM*, Dunworth M, Sharma G, Gentz M, Bracht S, Haynes M, Fertig EJ, Ewald AJ. Sci Transl Med. 2022 Aug 3;14(656):eabn7571.
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis. Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abelanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T. Cell Metab. 2021 Jul 6;33(7):1342-1357.e10.
Organotypic culture assays for murine or human primary and metastatic-site tumors. Padmanaban V, Grasset EM, Neumann NM, Fraser AK, Henriet E, Matsui W, Tran PT, Cheung KJ, Georgess D, Ewald AJ. Nat Protoc. 2020 Aug; 15(8): 2413–2442.
Informations complémentaires
Éloïse GRASSET, PhD.
One day, thanks to research doctors will say: don’t worry it’s just a cancer !
Laurine BERLAND, Graduate student.
