Pascal MARCHAND

Professor

Contact details

Head of Medicinal Chemistry Department & Deputy director EA1155 - IICiMed Institut de Recherche en Santé 2 Université de Nantes 22 Boulevard Bénoni Goullin 44200 Nantes, France

Office
226 (Bias - Teaching)
Phone
0253484133 (n° interne : 334133)
Fax
0240412876
Office 2
102 (IRS2 - Research)
Phone 2
0253009155 (n° interne : 329155)
Email
Pascal.Marchand@univ-nantes.fr
Personal Website
http://www.iicimed.univ-nantes.fr

Taught academic discipline(s)

Organic Chemistry, Medicinal Chemistry, Drug Design, Spectral Methods

Research topics

Design, synthesis and biological evaluation of heterocyclic compounds for therapeutic purposes (mycology, parasitology and cancer). Inhibitors of kinase signaling pathways. ADMET properties of molecules of biological interest. Microwave-assisted organic chemistry.

Activities / Resume

Academic qualifications    

Medicinal Chemistry department, EA1155 - IICiMed, Faculty of Pharmacy, Nantes.

September 2013: Professor of Organic Chemistry (1st class September 2016)

June 2007: Habilitation in Medicinal Chemistry - Design, synthesis and biological evaluation of azaheterocyclic compounds

September 2001: Assistant Professor in Organic Chemistry

January 2000-August 2001: Lecturer in Organic Chemistry
 
November 1999: PhD Thesis in Medicinal Chemistry - Synthesis and biological evaluation of indole derivatives as immunosuppressive and anti-cancer agents

June 1996: Master's degree in Pharmacochemistry

Involvement in postgraduate education/supervision/examination                    

PhD thesis supervisions (12): industry collaborations (Æterna Zentaris-Germany and Servier-France) and academic collaborations (Parasitology and Medical Mycology department of IICiMed team and international joint supervisions )

Dartagnan DE SÁ PIRES FERREIRA - Total synthesis and pharmacomodulation of cercosporamide, a natural product of promising biological interest - from April  2017. Co-director: Prof. Jefferson Luiz Princival, Recife - Federal University of Pernambuco, Brazil.

Marlene SARAIVA DE ARAÚJO NETA - Design, synthesis, physicochemical properties and molecular modeling study of novel heterocyclic thiosemicarbazones and thiazolidinones for the treatment of infectious diseases - from October 2016. Co-director: Prof. Antônio Rodolfo de Faria, Recife - Federal University of Pernambuco, Brazil.

Viet Hung DAO - Design, synthesis and biological evaluation of benzofuro[3,2-d] pyridines and dibenzo[b,d]furans, derived from cercosporamide natural product - 18th October 2018. Co-supervision: Dr I. Ourliac-Garnier.

Arsênio RODRIGUES OLIVEIRA - Design, synthesis and biological evaluation of new multi-target hybrid heterocyclic molecules - 10th July 2018. Co-director: Prof. Ana Cristina L. Leite, Recife - Federal University of Pernambuco, Brazil.

Juan Emmanuel REYNOSO LARA - Design and synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines substituted by an amide functional group as antimicrobial agents - 29th June 2018. Co-director: Dr Maria Elena Campos Aldrete, Mexico City - Institut Polytechnique National, Mexico.

Masters 2 (MSc) (13)

Postdoctoral researchers (8)

42 international publications and 4 international patents (h Index: 14)

Recent publications

P4. Winfield, H. J.; Cahill, M. M.; O’Shea, K. D.;  Pierce, L. T.; Robert, T.; Ruchaud, S.; Bach, S.; Marchand, P.; McCarthy, F. O. Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg. Med. Chem. 2018, 26, 4209-2024.

P3. Dao, V. H.; Ourliac-Garnier, I.; Bazin, M.-A.; Jacquot, C.; Baratte, B.; Ruchaud, S.; Bach, S.; Grovel, O.; Le Pape, P.; Marchand, P. Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: synthesis and evaluation of fluconazole susceptibility restoration. Bioorg. Med. Chem. Lett. 2018, 28, 2250-2255.

P2. Reynoso, J. E.; Salgado-Zamora, H.; Bazin, M.-A.; Campos-Aldrete, M. E.; Marchand, P. Design and synthesis of imidazo[1,2-a]pyridines with carboxamide group substitution and in silico evaluation of their interaction with a LuxR-type quorum sensing receptor. J. Heterocycl. Chem. 2018, 55, 1101-1111.

P1. Arruda Lima, S.; Gonçalves Melo, J.; Gadelha Militão, G. C.; Souza Lima, G. M.; Alves Lima, M. C.; Santos Aguiar, J.; Mendonça Araújo, J.; Braz-Filho, R.; Marchand, P.; Araújo, J. M.; Gonçalves Silva, T. Characterization of the biochemical, physiological, and medicinal properties of Streptomyces hygroscopicus ACTMS-9H isolated from the Amazon (Brazil). Appl. Microbiol. Biotechnol. 2017, 101, 711-723.

Recent publications and patent (continued)

International research collaborations (see: Other information)

PHC ULYSSES 2014 Programme - Ireland
CAPES-COFECUB 2015/2018 Programme - Brazil

Additional informations

International research collaborations

PHC ULYSSES 2014 Programme - Ireland
Campus France, responsible for the management of Hubert Curien Partnership (PHC) has selected the project ULYSSES 2014 filed jointly by the Department of Medicinal Chemistry of IICiMed team (Prof. Pascal Marchand, University of Nantes) and "Department of Chemistry and ABCRF "(Dr Florence McCarthy, University College Cork, Ireland). This collaboration, still in progress, is a work of Medicinal Chemistry in the field of Oncology that led to the mobility of students and project managers between the two sites.
 
CAPES-COFECUB 2015/2018 Programme - Brazil
The French Committee for the Evaluation of Academic and Scientific Cooperation with Brazil (COFECUB) in partnership with the CAPES (Coordenação de Aperfeiçoamento do Pessoal de Nível Superior, the Federal Agency of Support and Evaluation of Postgraduate Education) has selected the project submitted jointly by the team IICiMed (Prof. Pascal Marchand, University of Nantes) and the Department of Antibiotics, Biological Sciences Center (Prof. Teresinha Silva, Federal University of Pernambuco, Recife, Brazil). The research program, with duration of 4 years, entitled "Discovery of novel thiazolinones, thiazolidinones and quinones for the treatment of infectious diseases and cancer" is achieved through the mobility of researchers, PhD students and postdoctoral researchers, chemists and biologists.

Professional activities (member of committees/research clusters etc.)

Member of Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A) and President from September 2017.

www.gp2a.org