Personnel de l'université

Patricia LEMARCHAND

Professeure des Universités - Praticien Hospitalier, Directeur de la SFR santé F. Bonamy (UMS inserm 016 - CNRS 3556)

Coordonnées

SFR Santé F. Bonamy - UMS inserm 016/ CNRS 3556, l'institut du thorax - Inserm UMR1087/CNRS UMR6291, IRS-Université de Nantes, 8 quai Moncousu, BP 70721, 44007 Nantes cedex 1, France

Mail
Patricia.Lemarchand@univ-nantes.fr
Site internet
http://biocell.univ-nantes.fr

Discipline(s) enseignée(s)

Biologie cellulaire

Thèmes de recherche

Thérapie cellulaire cardiaque (recherche translationnelle, de la cellule souche aux essais cliniques).

Modélisation et étude de pathologies à partir de cellules souches iPSCs.

Etude de l'interface entre la recherche biologique et la pratique médicale (travail en collaboration avec Stéphane Tirard, Centre François Viète).

Activités / CV

Directeur de la SFR Santé François Bonamy (UMS inserm 016/CNRS 3556), Nantes.


Profil Google scholar

Corps

PU-PH

Informations complémentaires

Principales publications récentes :
Lamirault G, de Bock E, Sébille S, Delasalle B, Roncalli J, Susen S, Piot C, Trochu JN, Teiger E, Neuder Y, Le Tourneau T, Manrique A, Hardouin J-B, Lemarchand P. Sustainedquality of life improvement after intracoronary injection of autologous bonemarrow cells in the setting of acute myocardial infarction: results from the BONAMI trial. Quality of Life Research 2017; 26:121-125.

Braza F, Dirou S, Forest V, Sauzeau V, Hassoun D, Chesné J, Cheminant-Muller M-A, Sagan C, Magnan A, Lemarchand P. Mesenchymal stem cells induce suppressive macrophages through phagocytosis in a mouse model of asthma. Stem Cells 2016; 209:258-265.

Es-Salah-Lamoureux Z, Jouni M,Malak OA, Belbachir N, Reda Al Sayed Z, Gandon-Renard M, Lamirault G, GauthierC, Baró I, Charpentier F, Zibara K, Lemarchand P, Beaumelle B, Gaborit N, Loussouarn G. HIV-Tat induces a decrease in IKr and IKs via reduction in phosphatidylinositol-(4,5)-bisphosphate availability. Journal of Molecular and Cellular Cardiology 2016; 99:1-13.

Si-Tayeb K, Idriss S, Champon B, Caillaud A, Pichelin M, Arnaud L, Lemarchand P, Le May C, Zibara K, Cariou B. Urine sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia. Dis Mod & Mechanisms  2016;9(1):81-90.

Guijarro D, Lebrin M, LairezO, Bourin P, Piriou N, Pozzo J, Landes G, Berry M, Letourneau T, Cussac D, Sensebe L, Gross F, Lamirault G, Huynh A, Manrique A, Ruidavet JB, Elbaz M, Trochu JN, Parini A, Kramer S, Galinier M, Lemarchand P, Roncalli J. Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of theMESAMI 1 pilot trial. International Journal of Cardiology 2016; 209:258-265.

Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baró I, Zibara K, Lemarchand P, Gaborit N. Towards Personalized Medicine: Using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of LQT2 syndrome. J Am Heart Assoc 2015;4:e002159.

Gyongyosi M, Wojakowski W, Lemarchand P, et al. Meta-Analysis of Cell-basedCaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res 2015 16(8):1346-60. Best manuscript award 2015

Delewi R, Hirsch A, Tijssen JG, Schachinger V, Wojakowski W, Roncalli R, Aakhus S, Erbs S, Assmus B, Tendera M, Lemarchand P, et al. Impact of intracoronary bone marrow cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative meta-analysis. Eur Heart J 2014; 5(15):989-998.

Lamirault G, Susen S, Forest V, Hemont C, Parini A, Le Corvoisier P, Piot C, Richard MJ, Delasalle B, Rouard H, Sportouch C, Persoons V, Van Belle E, Roncalli J, Lemarchand P. Differential mobilization of progenitor cells in smoker and non-smoker patients with acute myocardial infarction: insights from the BONAMI biology sub-study. Stem Cell Res & Ther 2013; 4:152.

Roncalli J, Mouquet F, Piot C, Trochu JN, Le Corvoisier P, Neuder Y, Le Tourneau T, Agostini D, Gaxotte V, Sportouch C, Galinier M, Crochet D, Teiger E, Richard MJ, Polge AS, Beregi JP, Manrique A, Carrie D, Susen S, Klein B, Parini A, Lamirault G, Croisille P, Rouard H, Bourin P, Nguyen JM, Delasalle B, Vanzetto G, Van Belle E, Lemarchand P. Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction:  results of the randomized multicenter BONAMI Trial. Eur Heart J 2011; 32(14): 1748-1757.