• Du 15 January 2021 au 15 February 2021
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  • Expected starting date: March 1, 2021

POST-DOCTORAL FELLOWSHIP Spatial transcriptomics and bioinformatics on healthy and diseased human kidney A 2-year postdoc position is open to work at the Center for Research in Transplantation, Immunology (CRTI) in Nantes, France, in the fields of spatial transcriptomics applied to healthy, and diseased human kidney. MISSION(S) The successful candidate will work on an interdisciplinary EU-funded project (BIRDIE) to implement RNAseq techniques, including spatial RNAseq, for comparison between native human kidney samples and microphysiological models of the human renal tubulo-interstitium. The successful candidate will work in a large European consortium during the postdoc position ensuring excellent opportunities to interact and collaborate with other researchers in 3D bioprinting, microfluidics (OoCs), single-cell printing, RNAseq analysis and virology/immunology in transplantation. The position is intended as full-time.

ENVIRONMENT
Université de Nantes (UN) has approximately 38,000 students (10% of foreign students) enrolled each year, 1 doctoral college with 8 post-graduate schools and 3,200 research staff working in 75 accredited labs. UN has research agreements with industry and shares its discoveries with the society at large. As a multidisciplinary university, programs in most fields of knowledge and academic paths are offered. The Center of Research in Transplantation and Immunology (CRTI) is a Joint Research Units (UMR1064) affiliated to UN and INSERM (www.crti.univ-nantes.fr). The CRTI gathers researchers and clinicians with expertise in immunology, transplantation, autoimmunity, inflammation, virology, nephrology, regenerative medicine, genetic and bioinformatics. This research laboratory develops innovative projects going from basic to clinical research. The main objectives of these projects are to improve treatments and patient monitoring in transplantation and immune-mediated inflammatory diseases (IMIDs) through understanding immune responses, developing new immunotherapeutics, biomarkers, tools for personalized medicine and developing alternative strategies for organ or tissue replacement. The CRTI is organized in 5 independent teams and 11 core facilities, in which 35 scientists and a total of 175 people currently work to promote research, education and clinical developments. Together with the clinical departments of Clinical Immunology, Nephrology and Urology at CHU Nantes, it forms the Institute of Transplantation Urology Nephrology (ITUN). Both clinical and basic research is performed in the same building and physicians and scientists work together in research teams, thus providing excellent interactions between the clinical side and the laboratory in a translational research perspective. The kidney transplantation program of the ITUN is renowned worldwide and ranks amongst the best European centres. The CRTI has been involved in numerous FP7 and Horizon 2020 projects and has created 5 biotech companies IDBC (A2Com) (2000; www.idbc.fr), TcL and Expression (2002; www.firalis.com), Effimune now known as OSE Immunotherapeuthics, Xenothera, GoLiver and Aboleris Pharma. All the team of the CRTI are implicated within the laboratory of Excellence “immunegraft-oncology” (LABEX IGO) and the I-site Next initiative (www. next-isite.fr).
REQUIRED PROFILE
• Category A, contractual from the University of Nantes, 1 year renewable (24 months max).
• Remuneration: according to the management charter for contract workers from the University of Nantes for non-tenured staff (around 30k€ annual net salary).
• Training: applicants must possess a Ph.D. in bioinformatics or in biology.
• Publication record is required. Experience in research proposal and article writing is mandatory (technical and conversation English).
SKILLS AND KNOWLEDGE REQUIRED
General, theoretical and practical knowledge:
The candidate should have a proven record in the abovementioned fields with with a strong background in biology
and is expected to be skilled in:
- Managing biological sample preparation and RNAseq raw data generation from healthy and diseased
human renal tissues, tubule-interstitium microphysiological models,
- Analyzing transcriptomics data and doing bioinformatics analyses,
- Benchmarking, analyzing and displaying RNAseq data.
Operational know-how:
- I.T. expertise in the project management,
- Interact with other bioinformaticians, biologists, bioengineers and physicians (nephrologists),
- Guarantee the quality and relevance of analysis tools and results and reporting,
- Transmit knowledge and supervision of students.
Working Attitude:
- Ability to work independently as well as in a collaborative team environment,
- Adaptation and initiative capacities,
- Strong work ethics, communication skills and team player oriented personality.
• Expected starting date: March 1, 2021
• Candidates should apply by sending a CV, a cover letter (1-page only with significant achievements),
statement of research interests, and contact information for three references to: franck.halary@univ-nantes.fr
POST-DOCTORAL FELLOWSHIP