Personnel de l'université

Catherine LEVISAGE

Directeur de Recherche INSERM (DR2) / Directeur adjoint Unité Inserm U1229, Regenerative Medicine and Skeleton, RMeS

Coordonnées

INSERM UMR 1229, Regenerative Medicine and Skeleton, RMeS School of Dental Surgery, University of Nantes 1 Place Ricordeau - 44300 Nantes France

Tél
0240412984 (n° interne : 312984)
Mail
Catherine.Levisage@univ-nantes.fr
Site internet
http://www.rmes.univ-nantes.fr/

Thèmes de recherche

Hydrogel and joint microenvironment

To reproduce the complex 3 dimensional (3D) microenvironment experienced by cells in vivo, we have selected hydrogels, i.e complex networks of hydrophilic crosslinked polymers, for their similarity with the extracellular matrix of tissues. Our research is focused on natural, bioresorbable and non-immunogenic polysaccharides that are already commercialized for medical applications. We investigate hydroxypropyl methylcellulose (cotton) and pullulan (yeast fermentation) to design innovative hydrogels with tunable porosity and network diffusion parameters. Using various fabrication techniques, we develop chemically cross-linked hydrogels with complex architectures, tunable viscoelasticity and desired ability to mediate cellular activities through the spatial and temporal presentation of biological cues. We investigate hydrogels as i) tools for stem cell-based organogenesis and ii) carriers of cells or bioactive molecules for bio-inspired delivery strategies in cartilage and intervertebral disc regeneration.

Activités / CV

1996-1999          
 
Doctorant. Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie (CNRS UMR 8612), Faculté de Pharmacie, Châtenay-Malabry et Société VIRSOL, Paris (Contrat CIFRE). Directeur: Pr. Patrick Couvreur
 
1999-2003       Chercheur postdoctoral. Biomedical Engineering Dept, Johns Hopkins School of Medicine, Baltimore , USA (Pr. Kam Leong)
 
2003-2005                   Research Associate. Biomedical Engineering Dept, Johns Hopkins School of Medicine, Baltimore, USA
 
2005-2006  
 
Poste Jeune Chercheur Inserm. Unité Inserm U698, Bio-ingénierie Cardiovasculaire, Paris
 
2007-2013
 
Chargé de Recherche CR1 Inserm. Unité Inserm U698, Bio-ingénierie Cardiovasculaire, Paris
 
2013-
 
Directeur de Recherche DR2 Inserm. Unité Inserm U1229, Médecine Régénératrice et Squelette RMeS, Nantes
 
2017-  
 
Directeur-adjoint. Unité Inserm U1229, Médecine Régénératrice et Squelette RMeS, Nantes
 

Informations complémentaires

Recent publications
K. Flégeau, R. Pace, H. Gautier, G. Rethore, J. Guicheux, C. Le Visage*, P. Weiss P*
Advances in Colloid and Interface Science, 2017,
 
N. Henry, J. Clouet, A. Fragale, L. Griveau, C. Chédeville, J. Véziers, P. Weiss, J. Le Bideau, J. Guicheux*, C. Le Visage*
Drug Delivery, 2017; 24(1): 999-1010 - Full text available
 
N. Henry, J. Clouet, J. Le Bideau, C. Le Visage*, J.Guicheux*
Biotechnology Advances, 2017,
 
N. Henry, J. Clouet, C. Le Visage, P. Weiss, E. Gautron, D. Renard, T. Cordonnier, F. Boury, B. Humbert, H.  Terrisse, J. Guicheux, J. Le Bideau
Journal of Materials Chemistry B, 2017, 5: 2908-2920
 
MF Cutiongco, SH Goh, R. Aid-Launais, C. Le Visage, HY Low, EK Yim.
Biomaterials, 2016, 8 4: 184-95
 
N. Luciani, V. Du, F. Gazeau, A. Richert, D. Letourneur, C. Le Visage, C. Wilhelm.
Acta Biomaterialia, 2016, 37:101-10