Personnel d'un organisme de recherche

Julien BARC

En charge des projets portant sur la génétique des arythmies cardiaques à l’institut du thorax


Inserm UMR 1087/CNRS UMR 6291 IRS-UN - 8 quai Moncousu - BP 70721 44007 Nantes Cedex 1

0228080056 (n° interne : 320056)
02 28 08 01 30

Thèmes de recherche

Génétique cardiovasculaire
Cardiopathies et mort subite
Génomique des arythmies cardiaques

Activités / CV

Julien Barc, INSERM Associate Researcher at the Institut du Thorax since 2015, Nantes, France. After a 3-year PhD training in genetics of cardiac arrhythmia in Nantes, he spent 5 years at the department of Experimental Cardiology of Amsterdam, NL, where he gained experience in the new technologies and approaches in genetics. Today back within Dr. Schott’s group, he is leading the research on the genetics of arrhythmia. He is a member of the scientific boards of the Nantes genomics and bioinformatics core facilities and he is the co-leader of a national network for young fellows in cardiovascular research (Réseau Avenir GRRC).

After obtaining his PhD in 2009, he developed an independent research by obtaining a European Society of Cardiology research grant (2011), Van Gogh Programme (2012 and 2013) and the Lefoulon-Delalande Grant (2014). He received from the French Cardiology Society the prestigious Prize Edouard Coraboeuf 2014. More recently he obtained a H2020 grant on the complex genetics of the Brugada syndrome (2015) and a “rising star” grant from the regional council of Pays De La Loire  (2017) to develop cardiac epigenetic projects in Nantes with the aim to investigate the role of the non-coding regions of the genome in diseases at risk of sudden cardiac death.

Informations complémentaires

Researcher ID: K-5495-2014
  • 5 publications majeures: (*contributions équivalentes)

1. Familial Catecholamine-Induced QT Prolongation in Unexplained Sudden Cardiac Death

Huchet F*, Kyndt F*, Barc J*, Thollet A, Charpentier F, Redon R, Schott JJ, le Marec H, Probst V, Gourraud JB. J Am Coll Cardiol. 2017 Mar 28;69(12):1642-1643 (IF:19.9)

2. Role of common and rare variants in SCN10A: Results from the Brugada syndrome QRS locus gene discovery collaborative study

Behr E*, Savio-Galimberti E*, Barc J*, Holst A*, …/…, Guicheney P*, Crotti L*; Uk10k Consortium, Jamshidi Y*. Cardiovasc Res. 2015 Feb 17. (IF:5.8)

3. Mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence

Marsman RF*, Barc J*, Beekman L, Alders M, Dooijes D, van den Wijngaard A, Ratbi I, Sefiani A, Bhuijan ZA, Wilde AA, Bezzina CR. J Am Coll Cardiol. 2013 Sep 16. S0735-1097(13) (IF:19.9)

4. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Bezzina CR*, Barc J*, Mizusawa Y*, Remme CA*, Gourraud JB*, …/…, Wilde AA*, Probst V*, Schott JJ*, Dina C*, Redon R*. Nat Genet. 2013 Sep;45(9):1044-9. (IF:35.2)

5. KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

Louis-Dit-Picard H*, Barc J*, Trujillano D*, …/…, Hadchouel J*, Schott JJ*, Jeunemaitre X*. Nat Genet. 2012 Mar 11;44(4):456-60, S1-3 (IF:35.5)