Personnel de l'université

Sarah BECK

Chercheur CR, CNRS

Coordonnées

Unité Inserm UMR_S 1229 Laboratoire d'ingénierie Ostéo-Articulaire et Dentaire UFR d'Odontologie. 1 Place A. Ricordeau 44042 Nantes Cedex 01

Bureau
127
Tél
0240412821 (n° interne : 312821)
Fax
02 40 08 37 12
Mail
Sarah.Beck@univ-nantes.fr
Site internet
http://www.rmes.univ-nantes.fr/

Thèmes de recherche

Caractérisation des nouvelles fonctions intracellulaires des protéines PiT (co-transporteurs de sodium/phosphate, famille Slc20a) dans la physiopathologie du tissu squelettique par des approches in vitro et in vivo – Génération de nouveaux modèles murins permettant l’invalidation conditionnelle de PiT1 et/ou PiT2 dans le cartilage et/ou l’os au cours du développement et chez l’adulte. Etude des régulations réciproques entre adipogénèse et osteogénèse : rôle des protéines SLC20A.

Activités / CV

Sarah Beck-Cormier, née le 24 juillet 1975.

 

 FORMATION

- Post-doctorat : URA 2578/Institut Pasteur, Paris (2002-2006).

- Doctorat « Biologie et Pathologie des Epithéliums », Université Paris VII (2002).

- DEA « Biologie et Pathologie des Epithéliums », Université Paris VII (1998).

- maîtrise sciences et techniques « Biologie et Physiologie Appliquées », Université de Haute-Normandie (1997).

          

RESPONSABILITES ACTUELLES

- membre du conseil scientifique de la Société Française de Biologie des Tissus  Minéralisés (2012-2014)

- membre du comité de pilotage de l'animalerie UTE-IRS-UN, Nantes.

- membre du bureau de direction du laboratoire UMR_S1229

Informations complémentaires

Liste de publications (avril 2018) :

Bon N, Frangi G, Sourice S, Guicheux J, Beck-Cormier S, Beck L. Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2.
Mol Metab. (2018) doi: 10.1016/j.molmet.2018.02.007. [Epub ahead of print]

Bon, N., Couasnay, G., Bourgine, A., Sourice, S., Beck-Cormier, S., Guicheux, J., Beck, L*. Phosphate (Pi)-regulated heterodimerization of the high-affinity sodium-dependent Pi transporters PiT1/Slc20a1 and PiT2/Slc20a2 underlies extracellular Pi sensing independently of Pi uptake.
J Biol Chem. (2018) 9;293(6):2102-2114.

Merametdjian M., Beck-Cormier S., Bon A., Couasnay G., Sourice S., Guicheux J., Gaucher C., and Beck L. Expression of Phosphate Transporters during Dental Mineralization.
J Dent Res. (2018) Feb;97(2):209-217.

Lapérine O., Cloitre A., Caillon J., Huck O., Bugueno IM., Pilet P., Sourice S., Le Tilly E., Palmer G., Davideau JL., Geoffroy V., Guicheux J., Beck-Cormier S., and Lesclous P. Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis.
PLoS One (2016) Dec 19;11(12):e0168080.

Lapérine O., Blin-Wakkach C., Guicheux J., Beck-Cormier S., Lesclous P. Dendritic Cell-Derived Osteoclast: a new game changer in bone resorption-associated diseases.
Drug Discovery Today (2016) May 2. [Epub ahead of print]

Merametdjian M., David A., Bon A., Couasnay G., Guicheux J., Gaucher C., Beck-Cormier S. and Beck L. Expression of phosphate transporters in optimized cell culture models for dental cells biomineralization.
Bull Group Int Rech Sci Stomatol Odontol. 53(1): 16-27, (2016).

Souilhol C, Perea-Gomez, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M. NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo.
Development (2015) 142(21):3649-60.

Stedman A, Beck-Cormier S, Le Bouteiller M, Raveux A, Vandormael-Pournin S, Coqueran S, Lejour V, Jarzebowski L, Toledo F, Robine S and Cohen-Tannoudji M. Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells.
Cell Death and Differentiation (2015) 22(11):1865-76.

Rederstorff E, Rethore G, Weiss P, Sourice S, Beck-Cormier S, Mathieu E, Maillasson M, Jacques Y, Colliec-Jouault S, Fellah BH, Guicheux J, Vinatier C. Enriching a cellulose hydrogel with a biologically active marine exopolysaccharide for cell-based cartilage engineering.
J Tissue Eng Regen Med. (2015) Mar 30. [Epub ahead of print].

Beck-Cormier S, Escande M, Souilhol C, Vandormael-Pournin S, Sourice S, Pilet P, Babinet C, Cohen-Tannoudji M. Notchless Is Required for Axial Skeleton Formation in Mice.
PLoS One (2014) May 29;9(5):e98507.

Francuski, A. Radovanovi_c*, N. Andri_c*, V. Krsti_c*, D. Bogdanovi_c†, V. Had_zi_c‡, V. Todorovi_c*,x, M. Lazarevi_c Macanovi_c*, S. Sourice-Petit, S. Beck-Cormier, J. Guicheux, O. Gauthier and Filipovi. Age-related Changes in the Articular Cartilage of the Stifle Joint in Non-working and Working German Shepherd Dogs.
J. Comp. Path. 2014, Vol. 151, 363e374

Le Bouteiller M*, Souilhol C*, Beck-Cormier S, Stedman A, Burlen-Defranoux O, Vandormael-Pournin S, Bernex F, Cumano A, Cohen-Tannoudji M. Notchless dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells.
Journal of Experimental Medecine. 2013 vol. 210 (11) pp. 2351-69. * : co-first authors

Bourgine A, Pilet P, Diouani S, Sourice S, Lesoeur J, Beck-Cormier S, Khoshniat S, Weiss P, Friedlander G, Guicheux J, BeckL. Mice with Hypomorphic Expression of the Sodium-Phosphate Cotransporter PiT1/Slc20a1 Have an Unexpected Normal Bone Mineralization.
PLoS One. 2013 13 ;8(6) :e65979.

Beck, L., Leroy, C., Beck-cormier, S., Forand, A., Salaun, C., Paris, N., Bernier, A., Urena-Torres, P., Prié, D., Ollero, M., Coulombel, L., Friedlander, G. The phosphate transporter PiT-1 (SLC20A1) revealed as a new essential gene for mouse liver development.
PLoS ONE 5, 1-14, 2010.

Cormier S, Souilhol C, Babinet C, Cohen-Tannoudji M. Notch signalling pathway and early mammalian embryogenesis
Med Sci (Paris). Jan;23(1):26-8, 2007.

Haumaitre C, Fabre M, Cormier S, Baumann C, Delezoide AL, Cereghini S. Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations.
Hum Mol Genet. 15(15):2363-75, 2006.

Souilhol C, Cormier S, Vandormael-Pournin S, Babinet C and Cohen-Tannoudji M. RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development.
Mol Cell Biol. 26(13):4769-74, 2006.

Souilhol C*, Cormier S*, Monet M, Vandormael-Pournin S, Joutel A, Babinet C and Cohen-Tannoudji M. Nas transgenic mouse line allows visualization of Notch pathway activity in vivo.
Genesis. 44(6):277-86, 2006. * co-first authors.

Cormier S, LeBras S, Vandormael-Pournin S, Babinet C., Baldacci P and Cohen-Tannoudji M. The murine ortholog of Notchless, a direct regulator of the Notch pathway in Drosophila, is essential for survival of ICM cells.
Mol Cell Biol. 26(9):3541-9, 2006.

Benoist-Lasselin, C., de Margerie, E., Gibbs, L., Cormier, S., Silve, C. et al. (2006). Defective chondrocyte proliferation and differentiation in osteochondromas of MHE patients.
Bone 39: 17-26, 2005.

Cormier S, Leroy C, Délézoide AL, Silve C. Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development.
Gene Expr Patterns, 5(4) :569-73, 2005

Cormier S, Vandormael-Pournin S, Babinet C and Cohen-Tannoudji M. Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.
Gene Expr Patterns, 4(6) : 713-7, 2004.

Cormier S, Délézoide AL, Silve C. Expression patterns of parathyroid hormone-related peptide (PTHrP) and parathyroid hormone receptor type I (PTHR1) during human development are suggestive of roles specific for each gene that are not mediated through the PTHrP/PTHR1 paracrine signaling pathway.
Gene Expr Patterns, 3(1): 59-63, 2003

Cormier S, Délézoide AL, Benoist-Lasselin C, Legeai-Mallet L, Bonaventure J, Silve C. Parathyroid Hormone Receptor type 1 / Indian Hedgehog expression is preserved in the growth plate of human fetuses affected with Fibroblast Growth Factor Receptor type 3 activating mutations.
Am J Pathol 161(4): 1325-35, 2002.

Clemens TL, Cormier S, Anne Eichinger A, et al. Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets.
Br J Pharmacol. 134(6):1113-36, 2001.

Wysolmerski JJ, Cormier S, Philbrick WM, Dann P, Zhang JP, Roume J, Délézoide AL, Silve C. Absence of functional type I PTH/PTHrP receptors in humans is associated with abnormal breast development and tooth impaction.
J Clin Endocrinol Metab 86: 1788-1794, 2001