Synthèse de molécules à intérêt thérapeutique (nouvelles méthodologies, synthèse totale)
ENSEIGNEMENT :Cours de Chimie Organique : M1, M2
Travaux Dirigés de Chimie Organique : L1, L2, M1
Travaux pratiques de Chimie Organique : L2, M1, M1PC, M1CF
Travaux pratiques de Techniques de Séparation : L3 ICA
ACTIVITES DE RECHERCHE :
a) Chimie Organométallique : Réactions de Carbométallations
*
Diastereocontrolled Synthesis of Enantioenriched 3,4-Disubsituted delta-Polines :Dénès, F.; Pérez-Luna, A.; Chemla, F.
J. Org. Chem. 2007,
72, 398-406.
*
Radical-Polar Crossover Domino Reactions involving Organozinc and Mixed Organocopper/Organozinc Reagents:Dénès, F.; Cutri, S.; Pérez-Luna, A.; Chemla, F.
Chem. Eur. J. 2006, 6506-6513.
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Domino 1,4-Addition-Carbocyclization Reaction Through a Radical-Polar Crossover Reaction: Dénès, F.; Chemla, F.; Normant, J.-F.
Angew. Chem. Int. Ed.
2003, 4043-4046.
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Carbocyclization of Zinc Enolates onto Unactivated Double Bonds: a Mechanistic Point of View: Prian, F.; Sliwinski, E.; Dénès, F.; Chemla, F.; Normant, J.-F.
Comptes Rendus Chimie 2003, 67-68.
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Stereoselective Synthesis of Substituted Pyrrolidines by a Domino Michael Addition-Carbocyclization reaction: Dénès, F.; Chemla, F.; Normant, J.-F.
Eur. J. Org. Chem. 2002, 3536-3542.
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Diastereoselective Formation of Trisubstituted Pyrrolidine-3-carboxylate: Dénès, F.; Chemla, F.; Normant, J.-F.
Synlett 2002, 919-922.
b) Chimie radicalaire : Nouvelles méthodologies en chimie radicalaires
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Preparation of 5-Membered Rings via Radical Addition-Translocation-Cyclization (RATC) Processes Mediated by Diethyl Thiophosphite:Lamarque, C; Beaufils, F.; Dénès, F.; Schenk, K.;
Renaud, P.
Adv. Synth. Catal. 2011,
353, 1353-1358.
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Radical Cyclization of alpha-Bromo-Aluminum Acetals onto Alkenes and Alkynes: A Simple Access to Gamma-Lactols and 4-Methylene-gamma-Lactols: Boussonnière, A.; Bénéteau, R.; Zimmermann, N.; Lebreton, J.; Dénès, F.
Chem. Eur. J.
2011,
17, 5613-5627.
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Radical Cyclization of alpha-Bromo-Aluminum Acetal: An Easy Access to Gamma-Lactols: Boussonnière, A.; Dénès, F.; Lebreton, J.
Angew. Chem. Int. Ed.
2009,
48, 9549.
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Thiophenol-Mediated 1,5-Hydrogen Transfer for The Preparation of Pyrrolizidines, Indolizidines, and Related Compounds :
Dénès, F.; Beaufils, F.; Renaud, P.
Org. Lett.
2007, 9, 4375.
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Dimethylphosphite Mediated Hydrogen Atom Abstraction: a Tin-Free Procedure for the Preparation of Cyclopentane Derivatives: Beaufils, F.; Dénès, F.; Renaud, P.
Angew. Chem. Int. Ed.
2005, 5273.
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Highly Diastereoselective Formation of Spirocyclic Compounds via 1,5-Hydrogen Transfer: a Total Synthesis of (-)-Erythrodiene: Lachia, M.; Beaufils, F.; Dénès, F.; Renaud, P.
Org. Lett.
2005, 4103.
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Thiophenol-Mediated 1,5-Hydrogen Atom Abstraction: Eassy Access to mono- and Bicyclic Compounds: Beaufils, F.; Dénès, F.; Becattini, B.; Renaud, P.; Schenk, K.
Adv. Synth. Catal. 2005, 1587.
*
Thiophenol-mediated Hydrogen Atom Abstraction: an Efficient Tin-Free Procedure for the Preparation of Cyclopentanes Derivatives: Beaufils, F.; Dénès; F. Renaud, P.
Org. Lett.
2004, 2563.
c) Revue(s) :*
Addition of Metal Enolate Derivatives to Unactivated Carbon-Carbon Multiple Bonds:
Dénès, F.; Pérez-Luna, A.; Chemla, F. Chem. Rev. 2010, 110, 2366.
*Preparation of Five-Membered Rings via the Translocation-Cyclization of Vinyl Radicals:
Dénès, F.; Beaufils, F.; Renaud, P. Synlett 2008, 2389.
* Stereoselective Radical Translocation :
Renaud, P.; Beaufils, F.; Dénès, F.; Feray, L.; Imboden, C.; Kuznetsov, N. Chimia. 2008, 62, 510-513.
*Radical Cyclization of Haloacetals: the Ueno-Stork Reaction:
Salom-Roig, X.; Dénès, F.; Renaud, P. Synthesis 2004, 1903.
ACTIVITES ANNEXES :
Depuis 2006 - Membre du bureau de l'association "Sciences en Tête" - Organisation de conférences scientifiques "Grand Public"
L'université est membre